All About AMPK Activators

AMPK is the regulator that is maintaining cellular energy homeostasis which is basically the foundation of the body’s functionality. When it comes to AMPK in mammals, this works by regulating energy balance both on cellular level through sensing ATP/AMP and ATP/ADP ratio levels and at the same time, whole body by means of responding to the hormones and the brain.

ATP is actually the most significant energy molecule present in the body. In essence, this is the starting point of cellular function. ATP breaks down into ADP that has less potential for energy since the cells are using energy. Then after, ADP breaks down to AMP that has got the least energy potential among all 3. As a matter of fact, this is where AMPK becomes crucial by sensing if there is appropriate ratio among ATP/ADP/AMP and from there, tells the body if it requires more ADP to function properly.

There are different mechanisms in which AMPK acts on. Since the AMPK is considered as the master regulator for all functioning cells, it just makes sense. AMPK activation has an impact on the body which depends on the balance of signaling pathways and factors. Even so, there are some accepted benefits of increased AMPK activation including:

Anti aging – as we age, comes along with the gradual decline of AMPK activation. Experts actually think that AMPK is one of the contributing factors of aging. It is promoting cellular renewal and also, the production of new mitochondria.

Anti inflammation – interestingly enough, AMPK activation can help in decreasing inflammation but it can be decreased as well by inflammation.

Anti diabetic – the truth is, AMPK is becoming more and more understood when it comes to its role in diabetes treatment mainly because of the ability it has in enhancing insulin sensitivity.

There are so many herbal products/constituents as well as nutritional products that have been proven to be an effective AMPK activator and some of it include:

Number 1. AICAR – this is AMP’s analog which is required for cellular use and storage similar to ATP. Because it is AMP’s analog, AICAR has the capability of stimulating AMPK’s activity directly which can actually boost muscle performance.

Number 2. ALA – in this case, it’s Alpha Lipoic Acid that is known to be an effective antioxidant but it’s a useful AMPK activator too. It has been shown to greatly boost insulin sensitivity in the body and carrying anti obesity effects.

Number 3. Green tea extract – this helps in activating upstream kinase which then helps in activating AMPK.

Number 4. Berberine – because of its AMPK activation, berberine was discovered to carry the same anti diabetic effects as metformin.

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